Postdoctoral Fellow

A 100 % post-doc position is available in the Cancer Molecular Medicine group of Dr.Enserink at the Institute for Cancer Research at the Division for Cancer Medicine, from May 01, 2025 for three years (two years with one year extension). The start date can be negotiated.

The candidate will contribute to a project aimed at unraveling the function of newly identified regulators of autophagy using the model organism budding yeast (Saccharomyces cerevisiae).

The research focus will involve:

• Transcriptomics/translatomics (transcription/translation factors)
• Analysis of autophagy phenotypes using live cell microscopy

The organization and research focus
The Cancer Molecular Medicine group is located at the Radium Hospital, which is part of Oslo University Hospital, the largest academic hospital in Scandinavia. The group is part of a Norwegian Centre of Excellence (Centre for Cancer Cell Reprogramming, "CanCell"), which consists of six research groups focused on the discovery of cancer programs and the interactions of cancer cells with the cellular environment.
One of the group's aims is to comprehensively explore autophagy dynamics in response to nutrient stress, employing genomics and computational biology and yeast as a model organism. In our latest project, we delivered a systems-level description and characterization of the global regulatory network governing autophagy dynamics during nitrogen starvation and replenishment. Based on these findings, we are interested in examining autophagy dynamics under various nutrient conditions and elucidating the relationship between autophagy dynamics and internal metabolic circuits. This post-doc position will focus on validating several hits identified in a recently completed genome-wide study of autophagy in yeast, with particular focus on transcription and translation factors.

More information about the group can be found at:
https://www.ous-research.no/enserink/
https://www.med.uio.no/cancell/english/groups/cancer-molecular-medicine/publications/

The location
The group is located at the Radium hospital campus of Oslo University Hospital in Oslo, Norway.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial to solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and encourage all qualified candidates, regardless of background, to apply.

Position requirements

We are looking for:

• A talented, enthusiastic and determined person. The successful candidate is highly self-motivated and can work independently as well as constructively in the context of a team. This work will be conducted in tight collaboration with a highly interdisciplinary team, which requires strong and effective communication and personal skills.
• The candidate has robust work ethics and is focused on delivering high-quality data.
  Potential candidates have completed (or are very close to completing) a PhD degree in biology or natural sciences with a focus on cellular or molecular biology.
• The successful candidate is positive-minded, is looking forward to learning new techniques and is well organized. Fluent oral and written English communication skills are essential.

Essential scientific qualifications

• Experience with molecular biology and/or cell biology methods, with strong preference for yeast methods
• Experience with preparing figures and scientific reports
• Proficiency in statistical methods and the use of tools such as R and graphpad

Advantageous skills

• Experience with high-throughput screens and -omics methodologies, especially transcriptomics, single-cell transcript analysis, translatomics, proteomics.
• Proficiency in bioinformatics, such as coding and/or computational -omics data analysis.
• Experience with fluorescence live cell imaging microscopy.
• Knowledge of methods required for analysis of metabolism, nutrient signaling and/or autophagy.
• Experience with working with yeast, e.g. Candida, S. cerevisiae, S. pombe.
  

We Offer

• A dynamic and exciting research theme in a positive, collaboration-minded research team with excellent opportunities for further academic development.
• Participation in a stimulating and robust research project strongly connected to other research groups in the center of excellence.
• A research environment with state-of-the-art core facilities and excellent international network.
• Career coaching, such as training in grant writing and lab management.
• Full-time three-year position (two years + one year extension).
• Salary as stipulated by the guidelines from Oslo University Hospital
• Flexible work hours.
• Attractive welfare benefits and a flexible work environment that promotes a robust work-life balance and family-friendly environment.
• It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

How to apply
Interested persons should submit the following documents to Webcruiter:

• A concise application letter (1-2 pages) explaining why you are the best candidate for this position.
• Curriculum vitae, including a list of publications (manuscripts on BioRxiv can be included).
• Three recent reference letters, including contact information of all the references (email address, postal address, phone number and relation to candidate).
• Please note that applications lacking any of these three requirements will be discarded automatically. The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”. Only applications in Webcruiter will be evaluated.
• Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language). In assessing the applications, special emphasis will be placed on the documented academic qualifications, as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.