Join our Radiochemistry team!

As a Lead Radiochemist in the Pharmaceutical Diagnostics Research and Development, Radiochemistry team you will play a pivotal role to identify and develop novel radiolabelled Molecular Imaging (MI) products within a multidisciplinary Chemistry Manufacturing and Controls (CMC) development team. The role requires the development of MI manufacturing methods suitable for clinical translation and registration/commercialisation. Key business areas are neurology, oncology and cardiology, where GE HealthCare provides MI products across the imaging modalities PET and SPECT.

Essential Responsibilities

• Developing radiolabelling methods suitable for reliable supply of radiopharmaceuticals through pre-clinical and clinical translation and ultimately for commercial production.
• Defining and performing radiochemistry laboratory experiments and collaborating remotely with others performing the experimental radiochemistry work.
• Working in multidisciplinary scientific teams and with people from across the different functions of the business.
• Authoring suitable scientific reports & documentation to support regulatory documentation packages (e.g., internal development reports, IND, IMPD, NDA, MAA, research publications, etc.).
• Performing projects and technology transfers with academic partners and external contract R&D organisations.
• Providing radiochemistry development expertise to support products across the wide development stages from early development to life-cycle management.

Qualifications/Requirements

• PhD/MSc in Radiochemistry or Chemistry or equivalent knowledge or experience.
• Hands-on experience in [18F]fluoride and other radionuclide radiolabelling techniques for small and large molecules using direct or synthon-based methods and strong scientific knowledge of the established chemistries used in diagnostic MI products.
• Experience with academic and/or commercial MI product development/production.
• Strong English communication skills.

Desired Characteristics

• Organised approach for planning and delivering within complex scientific projects.
• Demonstrable practical knowledge of analytical techniques and methods used in the characterisation and release of radiopharmaceuticals.
• Understanding of regulatory requirements for development of radiopharmaceuticals.
• Experience in CMC development, including automation of radiopharmaceutical manufacturing processes.
• A good track record of collaborating with external partners.
• Experience with current Good Manufacturing Practice requirements.
• Responsible, compliant, and highly ethical mindset.
• Strong awareness of safety and risks.
• Demonstrated initiative, problem-solving skills and analytical organisation.
• Ability to resolve problems and exercise sound judgment in ambiguous environments.